Wednesday, September 2, 2020

Implications for HR Practices in Other Companies LIKE Zappos.com Research Paper

Suggestions for HR Practices in Other Companies LIKE Zappos.com - Research Paper Example HR Lessons from Zappos.com A comparative organization in internet retailing is Modcloth.com. It has been in activity for just two years, so it has a long way to go as far as having an obvious hierarchical culture. Zappos.com set aside the effort to characterize what its organization culture is, and afterward ensured that all people who worked for it fit into the way of life. Everything else that they did was a branch of this boundary (Palmeri, 2009). Hence, Modlcoth.com can gain from this organization by doing likewise. They should choose the qualities and standards that will assist them with accomplishing their objectives. When this is done, at that point the association can concentrate on other key components. Modcloth.com may likewise copy the degree to which hierarchical culture is a moral obligation regarding all staff at Zappos. Modcloth regards hierarchical culture as a human-asset issue yet Zappos adopts an entirely unexpected strategy. Zappos likes to consider everybody resp onsible for the support of their way of life. People regularly progress in the direction of this segment in each part of their employments. This culture is caught in ten explanations that incorporate â€Å"Being audacious and inventive, â€Å"being humble† and â€Å"pursuing development. The proactive nature wherein Zappos diffuses its qualities may likewise be utilized by administrators in Modcloth.com. They ought not simply anticipate that their workers should find their qualities autonomously. Preparing for new specialists ought to include finding out about the company’s style. Modcloth.com can profit by showing representatives expressly about these issues before they permit laborers to cooperate with customers. Sephora.com is a profoundly fruitful beauty care products online retailer. Its HR rehearses, notwithstanding, don't reflect this new-age approach. Their employing procedure is something that needs improvement. It ordinarily does a specialized enrollment pr ocess with a little spotlight on hierarchical culture. Zappos.com centers around a person’s fit with the organization culture during enlistment. They accept that having specialized aptitudes won't yield considerable outcomes if these can't convert into their qualities. Thusly, they don't settle on it. Recruiting forms typically keep going for a generally prolonged stretch of time. The firm expects work possibility to go to at any rate one departmental and friends occasion as meetings proceed. This prompts the energy about authoritative qualities. Here and there some enrollment procedures may keep going for as long as four months (Inghilleri and Solomon, 2010). In Zappos’ enrollment, questioners regularly pose six inquiries that are probably going to decide the person’s conduct. For the most part, these inquiries are intended to evaluate the degree to which a candidate’s conduct fits in with the organization culture. Be that as it may, a few pieces of the meeting will likewise take a gander at the applicant’s abilities. Sephora can gain so much from these recruiting rehearses. To start with, they should enlist for their guiding principle. Besides, they should have a structure to follow while enlisting. Sephora.com typically leaves parts of the recruiting procedure in the possession of experts, and what they choose is the last word on the issue. This implies straightforwardness is a test. Zappos.com has an exceptionally straightforward recruiting process. When a meeting has been finished, the questioner is relied upon to decide on whether the competitor ought to be employed or not. These people regularly enter their criticism into a PC. They are likewise expected to give clarifications for why

Saturday, August 22, 2020

Marketing Grocery Essay Example | Topics and Well Written Essays - 1750 words

Advertising Grocery - Essay Example Large scale ecological Factors Large scale ecological components are the natural factors that influence the advertising methodologies of the association in spite of the fact that it has restricted odds of controlling them. They incorporate political-legitimate, socio-social, global and mechanical variables. The association can characterize these variables regarding checking for better comprehension all things considered and dangers it might confront along with the necessary key gadgets to modify so as association can accomplish and keep up upper hand (Kotler and Armstrong, 2006). Full scale ecological components start from outside of the association and they can't be changed by the organization’s activities. Explicitly an association can get incredible difficulties when there changes in this factor of condition however the association itself can't influence the earth. Enactment The legitimate condition powers associations to become complex while influencing business tasks straightforwardly. It is hard for organizations to work their exercises without meeting commitments identifying with guidelines of the law. A portion of the guidelines that may influence bussines associations incorporate industrialism guidelines, serious and relations of workers. The majority of guidelines are related with administrative offices. The US has the ground-breaking administrative organizations that incorporate Occupational Safety and Health Administration (OSHA), Equal Employment Opportunity Commission (EEOC), Environmental Protection Agency (EPA) and numerous others. Consistence cost of the guidelines is extravagant albeit the vast majority of them are passed on buyers toward the end. This implies the greater part of the item prizes might be high to meet the prerequisites of the considerable number of guidelines. Consequently, the associations ware promoting cost relies intensely upon the legitimate prerequisites (Schmidt, 2005). Socio-social Factors Socio-social components of condition includes customs, qualities and ways of life that give the attributes whereupon the association works. Socio-social elements of condition influences the capacity of an association to get assets, think of its own administrations and work inside a general public. Social-social elements involves all perspectives inside the general public that can impact the exhibition of an association. They can incorporate extending instructive levels, populace socioeconomics, qualities and standards along with the disposition towards social duty (Schmidt, 2005). Mechanical Factors Technology is a factor that influences the advancement of key plans of an association. Variety in innovation may lead extraordinarily impact the interest of the associations products and ventures. It might likewise influence its handling procedures and the necessary crude materials for assembling products. The changing of innovation can impact an association in two different ways. To begin with, it might give new chances to the association to investigate and show signs of improvement returns. Then again, it might make dangers the endurance status of the association, the item or industry. Innovative enhancements keep on expanding at an exceptionally high rate, which necessitates that all organizations be a steady transformation to endure. Equalization of Payment Balance of installment is the net distinction in merchandise that purchased and sold by representatives of a nation. It

Friday, August 21, 2020

DNA Retention for Criminal Investigation Assignment

DNA Retention for Criminal Investigation - Assignment Example The current paper has recognized that in 2003, the law was adjusted to gather DNA on the capture of a recordable wrongdoing instead of only a state of charge. This guideline of keeping up the DNA of anybody captured featured innumerable honest individuals including kids who had never been sentenced yet have their DNA held in the Database until the end of time. Along these lines, the DNA database is considered incredibly oppressive. In the year 2008, this issue was raised by the European Court of Human Rights in S and Marper v UK case and inferred that this approach damages the rights to security of blameless individuals under the European Convention of Human Rights. At that point in 2010, in answer to this issue, the law was passed which confines the DNA maintenance of blameless individuals. Six years was affirmed for the grown-ups and three years for kids. (Michael Lwin, 2010) Still, this strategy kept on making segregation and remained doubtful among numerous areas. In 2010, the Go vernment was again constrained to adjust the law and move to the ‘Scottish model’ which characterizes the option to obliterate DNA of anybody captured however not charged or charged yet later saw not as liable for most offenses. It likewise clarifies the arrangement of restricted time DNA maintenance for individuals who were accused of genuine bad behaviors like rape or savagery (Bruce Barbour; NSW Ombudsman.; New South Wales. Office of the Ombudsman, 2006). The assortment of DNA tests are as yet a significant subject of segregation among numerous guiltless individuals. It has given a huge blast to social and moral issues which are on the grounds that most arrestees were discovered guiltless of the wrongdoing yet their DNA was saved for an inconclusive time. Also, if blameless people’s DNA is kept in a police database, it is conceivable that the DNA may coordinate or incompletely coordinate the DNA found at the areas of wrongdoing. This can make a major issue for an individual who has been once captured however never sentenced or any individual who is absolutely blameless. This issue is morally and socially right as blameless individuals would be associated with crimes at the wrongdoing scene where their DNA is even marginally comparable. A DNA test shows touchy data about an individual’s hereditary qualities, for example, family relations and maladies weakness. Normally, nobody loves their own data to be open. Police, measurable science division and scientists utilizing this delicate data without the assent of the DNA viewer have insulted any blameless individuals who have given their DNA. They consider it to be an infringement of their common freedoms and obstruction in the individual security of an individual ( Andromachi Tseloni; Ken Pease, 2011). It has been seen in the United Kingdom’s criminal DNA database that racial minorities are overrepresented in the quantity of arrestees. Presently this offers ascend to racial c ontrasts and regulated racial predispositions in the criminal equity office. At the point when countless minorities are populating the DNA database, police would probably presume one from the minorities instead of the genuine lawbreaker. Along these lines an honest individual would be sentenced simply because for the race he falls in. DNA maintenance for the Criminal Investigation Department has raised a few worries among numerous honest individuals yet we should not ignore the great it accomplishes for the lawbreakers who ought to be really rebuffed. DNA maintenance serves the police division from numerous points of view as well. In like manner, it is seen that most of the violations are submitted by the individuals who have been as of now captured for different offenses. In the event that the DNA database as of now has the DNA bank, it could turn out to be exceptionally simple for the police to recognize the suspect or criminal.â

Tuesday, May 26, 2020

Why You Should Visit Our Country As a Topic of an Essay

Why You Should Visit Our Country As a Topic of an EssayWhy you should visit our country is an important question in some students minds. Students who are afraid to visit our country due to fear of school problems, which they don't have, or who just can't face travelling are not the best candidates for writing a persuasive essay. Your purpose in writing a persuasive essay is to convince your reader to visit our country so that they can take home some 'forbidden' photos, documents, and other things.While you are studying, write the following paragraphs in order for you to prepare yourself for the interesting test of an interesting essay and for writing a persuasive essay sample. Write why you should visit our country as the topic of an essay on college entrance exam. You may also make the introduction or conclusion more interesting by giving some ideas for your readers about why you should visit our country.We should visit our country for many reasons. First, we should visit our countr y because it is fun. For many countries, it is very common to go abroad to have fun. A lot of our political leaders and other leaders have visited other countries to experience the fun and relaxation that this kind of travel can give them.The second reason for visiting our country is to communicate with the politicians and many other people who can explain the interesting points of our country. Some of these people can be leaders of other countries. They can also be leaders of major religions. It is their duty to help us spread the good values of our country to other countries.Another important event that should be covered in a persuasive essay is the day that it became a recognized country. There are several countries that were once considered to be 'inferior' to our country and no one ever wanted to visit them. Today, these countries have become our neighbors and they often send their leaders to visit us. But most importantly, they help us spread the good values of our country.Why you should visit our country is a very important question for any student or for anyone who has traveled to other countries. This question is very easy for students and people who have already experienced visiting another country to answer. In this case, the right answer is 'Because it is fun.' The country you visit may be much different from the country you lived in but if it is fun, then you will get the same feeling as you would in your home country.Students need to practice writing persuasive essays as they do not want to feel lost if they will need to answer this question in a class or in a thesis. Practicing how to write persuasive essays will help them get an essay to meet the standards of the exam. It will also help them to impress the school officials, the parents and other parents of the school and it will help them to impress the college officials.

Saturday, May 16, 2020

Capital Punishment Should Be Abolished - 2070 Words

Death, a dark and mysterious activity, the ultimate price for committing a capital crime (SC #18). A jury selected at random decides the fate of the offender. Throughout history, the idea of capital punishment has been brought into question. The argument that always arises is if capital punishment should be abolished or not. Capital Punishment has an extensive history and a debatable future; reasons such as religion, morals, justice, and satisfaction have caused differing views among Americans, resulting in multiple sides and changing viewpoints. The idea of capital punishment has been around since the Eighteenth Century B.C., the early executions were barbaric and gut wrenching to view (BE #1). The Code of King Hammurabi of Babylon was the first known accepted capital punishment. It stated that twenty-five crimes were punishable by death. Centuries continued to pass, and more civilizations integrated the death penalty into their societies. In the Roman law of the Twelve Tablets alm ost every crime could be punishable by death. Countries dealt with capital punishment differently. The Romans chose to crucify, drown, assault, burn alive, and impale the offender as a way to punish them. These extensively painful ways of death were carried out regularly and without hesitation. Crimes could vary from capital crimes such as murder and rape to petty crimes such as theft and trespassing. Capital punishment started to spread throughout the world, and the British Monarchy adopted itShow MoreRelatedCapital Punishment Should Be Abolished965 Words   |  4 PagesHaesemeyer Advanced Studies English 9 7 April 2017 Capital Punishment Over the centuries, capital punishment has fallen in and out of public support. In several countries, the practice has been overruled by law. In others, it is simply not exercised. More than half of U.S. states still practice capital punishment for capital crimes. Often, innocent people are sentenced to death because of circumstantial evidence. Capital punishment should be abolished in all fifty U.S. states because of the severalRead MoreCapital Punishment Should Not Be Abolished1541 Words   |  7 Pagestime, if a person committed a severe crime, like murder or rape, they were executed to maintain peace in the community and to bring comfort to those who knew the victim. Capital punishment has been used in almost every part of the world, but in the last few decades many countries have abolished it. The issue of capital punishment has been a sensitive topic for nations attempting a careful balancing act between prisoner’s rights and legal defense teams and society’s la ws on cases of extreme gravityRead MoreCapital Punishment Should Not Be Abolished901 Words   |  4 Pagesgovernment (â€Å"Capital Punishment in the United States†). Capital punishment is being debated all over the world whether it is murder or justice for the crime they have committed. Statistics show that murderers often kill again after releasement from prison. The Bureau of Justice gives relevant statistics pertaining to murderers who were released from prison: in 1994 40.7% of murderers were arrested for a new crime within three years of release (United States Department of Justice). Capital punishment shouldRead MoreCapital Punishment Should Be Abolished1115 Words   |  5 Pagesjail time, house arrest, and/or having to pay fines. Crimes that are severe can lead to greater punishment, like spending life in prison. The most severe crimes can lead one to an equally severe punishment known as capital punishment. Capital punishment is the authorization to kill someone fo r the crime he or she has committed. Capital punishment, commonly referred to as the death penalty, should be abolished in all states because it can put innocent lives at risk, it costs millions of dollars each yearRead MoreCapital Punishment Should Not Be Abolished750 Words   |  3 PagesCapital Punishment Should Not be Abolished There are many reasons why the United States of America keeps capital punishment. These reasons include the deterrence theory, the idea of retribution, cost of prisons, and general safety of the public. First of all, I’m sure that you have heard of the deterrence theory. Deterrence is basically the fear of punishment; and even though it doesn’t prevent all crimes, the results are still undeniable. The deterrence theory is when criminals thinkRead MoreCapital Punishment Should be Abolished883 Words   |  4 Pages Capital punishment is the punishment of death for a crime given by the state. It is used for a variety of crimes such as murder, drug trafficking and treason. Many countries also have the death penalty for sexual crimes such as rape, incest and adultery. The lethal injection, the electric chair, hanging and stoning are all methods of execution used throughout the world. Capital punishment has been around since ancient times; it was used in ancient Rome, and one of the most famous people to be crucifiedRead MoreCapital Punishment Should Be Abolished1137 Words   |  5 PagesThe case for capital punishment Topic: why capital punishment should continue General purpose: To argue Specific purpose: my main aim is to convince the audience that capital punishment should be upheld. In other, the advantages of capital punishment outweigh its disadvantages. Introduction Capital punishment is also known as death penalty and it has been in existence since time immemorial. Throughout history, the death penalty has been used to punish a number of crimes that include murderRead MoreCapital Punishment Should Be Abolished1955 Words   |  8 Pagesit has become apparent that capital punishment should be abolished worldwide. Around the world, various countries continue to practice this brash, inhumane punishment. The legal system is intended to regulate citizen’s behaviour which aims to provide a smooth functioning society. When someone is sentenced to death, the legal system loses the â€Å"fair† aspect of the proceedings, as under no circumstances is the death penalty â€Å"fair†. Capital punishment should be abolished because it violates Section 12Read MoreCapital Punishment Should Be Abolished1135 Words   |  5 Pagesname -unknown. Nobody should ever have to hear these words. Especially coming from their own state the one that is supposed to protect their rights no matter what. Capital punishment should be abolished from the United States. The number one goal of the constitution is to protect the life of an individual and the death penalty passes by this. The death penalty is an easy way out of the crime, it is expensive, philosophers and even psychologists disagree with capital punishment and most important itRead MoreCapital Punishment Should Be Abolished Essay1293 Words   |  6 PagesApproaching the topic of capital punishment is difficult when looking at society as a whole. In the opinion stated by my class group, capital punishment should be entirely abolished due to the possibility of mistakes while sentencing. This idea relies on the basis that capital punishment has absolutely no purpose or benefit. Members of my group mistakenly used a utilitarianist point of view to argue their case, even though this view can be stretched to fit almost any argument. This paper will explore

Wednesday, May 6, 2020

Human Development Notebook Essay examples - 3460 Words

Human Development Notebook [Part One] Laura Douthat EDF 3214 Sept. 27, 2010 Brain and memory Principles and theories When a human child is born, their brain is not yet fully developed. This development takes place over time and involves neurological processes as well as environmental stimulation. Babies have all the neurons that they will ever have at the time of their birth. Neurons are the structures that enable brains to store and transmit information (Woolfolk, 2010, p.29). The connectors which allow the information from the neurons to travel across the brain are not developed at this time, however. These fibers, called axons and dendrites, continue to mature throughout the early stages of the child’s life. How†¦show more content†¦144). Some other techniques for improving the learning experience of students with autism are structured teaching, speech and language therapy, social skills therapy, and occupational therapy. Keeping a structured and predictable schedule is imperative when instructing a child with autism. The child will also, most likely, need some specialized classe s in speech as well as instruction in appropriate social interaction, as one symptom of autism is a lack of comprehension of social norms. Educators need to keep in close contact with the team responsible for the student’s educational plan and diagnostic write-up to ensure that there are no large gaps in the educational programs suggested and the ones being applied. Physical development Principles and theories Physical development is defined as changes in body structure and function over time (Woolfolk, 2010, p.559). There are two main principles involved in the physical development of humans. Normal human development progresses from the head down. When born, babies’ heads are disproportionately large in comparison to the rest of their bodies. In fact, a baby’s head is approximately one-fourth of the size of their entire body. Over time, the body size increasesShow MoreRelated Leonardo Da Vinci Essay1729 Words   |  7 Pagesno power to quote from authors as they do I shall rely on a bigger and more worthy thing-on experience.{The Notebooks of Leonardo Da Vinci pg.2} His originality in the field of painting influenced the course of Italian art for more than a century after his death, and his scientific studies--particularly in the fields of anatomy, optics, and hydraulics--anticipated many of the developments of modern science. His amazing powers of observation and skill as an illustrator enabled him to notice and recreateRead MoreCommunication and Family974 Words   |  4 PagesThe written word is arguably humanity’s most powerful tool. Writing allows for the sharing of ideas, memories, and events, all facets of the human experience. Such communication plays a pivotal role in the development and growth of our current, complex society. Moreover, the written word transverses time and space, thereby connecting humans to one another in a manner beyond compare. As demonstrated by the world’s past, written works have changed the course of history altogether. Harriet BeecherRead MoreNaturalistic Observation Essay623 Words   |  3 Pagesï » ¿ Naturalistic Observation In order to study human development and perform naturalistic observation I went to the mall. I selected a 9-year-old white girl as the subject for my observation. I observed the subject for 30 minutes. During my observation the subject was not interrupted and was not aware of my study. The girl was spending time with her mother and brother at the mall. She was enjoying herself. She played some games with her brotherRead MoreDevelopment Of The First Operating System1728 Words   |  7 PagesSince the development of the first Operating System (OS) to today, there have been many vast and extraordinary improvements, including the introduction of the first QWERTY keyboard, the first Graphical User Interface (GUI), to the present day mobile computing capabilities of smart phones. There have been many drastic changes from the first computers to today’s modern PC, which has become an essential component of our everyday lives. 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A well documented notebook contains notes, calculations, signatures, and dates. Keeping good note can make an accurate document for an original design. 8. Outline the mainRead MoreThe Importance Of Contact Information For The Director And Content Specialists1318 Words   |  6 Pagesin triplet meetings and officer transitions to help ensure a smooth transition and transfer of materials and information. Keep a well-organized, complete notebook to provide continuity from one adviser to the next. Train successor. Adviser Notebooks Each adviser, regardless of her committee assignment, should keep the following items in a notebook or in a file electronically that she brings with her to Advisory Board meetings and meetings with her committee or officer. The contact information for the

Tuesday, May 5, 2020

Neuroscience and cell biology

Question: Discuss about the potential of neuroprotective and cell-replacement therapies as Disease modifying therapies for Parkinson's diseas? Answer: Introduction Parkinson disease is the neurodegenerative disease. This common disease affects people over 65 years age (Buttery and Barker 2014). The disease is characterised by progressive degeneration of the dopaminergic neurons that leads to disability of movement. It is due to presence of alpha-synuclein positive Lewy bodies in the substantia nigra. Lewy bodies are identified to be associated with the non-motor features of the disease such as sleep, cognitive an autonomic dysfunction. Among most restorative therapies to the disease are neuroprotective factor therapy and cell replacement therapy. Experiments with this approaches showed promising results. The paper discusses the potential of neuroprotective and cell-replacement therapies as disease modifying therapies (alternative to drug therapy) for Parkinson's disease. Discussion According to Barrow (2015) stem cell therapy has been found to have exciting prospects in treatment of Parkinsons disease. It has been effective in treating several neurodegenerative conditions. Some of the experiment with high potential to treat parkinsons disease have been discussed below. In patients with this disease, the central nervous system or CNS does not regenerate its own neurons. Hence, stem cells are a good choice as they have pluripotency. Initiating the differentiation of the stem cells under correct conditions will help generate dopminergic neurons, which can then be transplanted into the patients for replacing their dopamine levels. Both Michael J Fox Foundation and Parkinson's UK actively research into potential stem cells therapy (Kim et al. 2002). Kriks et al. (2011) showed that in an animal model of Parkinsons disease, when dopamine neurons extracted from the embryonic stem cells were transplanted it showed to function effectively. These neurons have ability to efficiently engraft in the animal model. There was an improvement in dopaminergic delivery to the neighbouring parts when these neurons got established within the striatum. It aids in improving the motor control and preventing the worsening symptoms of the illness. Induced pluripotent stem cells or iPS have properties same as ESCs. They can be derived from adult human dermal fibroblasts. iPSs has obvious potential for Parkinsons disease as cell based therapy (Canet-Aviles et al. 2014). However, eliminating their tumour inducing property will make them highly suitable for cell therapy. It is devoid of ethical problems as the iPSs can be derived from pateints own adult cells and there is no risk of rejection. The cell line of iPS called IMR90clone 4 is available which can be differentiated into dopaminergic neuron progenitors. Upon transplanting it into the rat disease model these progenitors were found surviving for a very long period. In other experiment iPSs having point mutation in -synuclein (A53T) were developed for the disease. After transplantation the mutation was reversed via zinc finger nuclease genetic editing successfully. Later functional dopaminergic neurons were generated (Pawitan 2011). Other potential method of cell replacement therapy is the implantation of the neural stem cellsor NSC into the striatum of the effected patients (Buttery and Barker 2014). With the help of the extracellular signalling, these cells were differentiating into dopaminergic neurons as a response to the host body signals. An intrinsic ability of NSCs is to generate neuroprotective factors by influencing the CNS. However, there is a need of providing appropriate in vitro signalling. It was evident from the study that the adult stem cells have higher potential than the embryonic stem cells. Additional advantage of the adult stem cells is that it can be extracted from other sources such as oral mucosa, adipose tissue and bone marrow. It does not depend on the aborted foetal tissues. This potential therapy was successful when applied to Mr. Dennis Turnerin the USA. He was a patient of Parkinsons for 14 years and he himself have declared the benefits of cell replacement therapy. The most promising disease modifying therapy for Parkinsons disease is Neuroprotection and neuroregeneration. As per Lu-Nguyen et al. (2014) the Neurotrophic factors have the potential to act as disease modifying treatment among the current research strategies as they play significant regulatory role in the development, and survival of specific populations of neurons. They can also reverse the loss of nigrostriatal dopaminergic neurons. The main cause of symptoms in Parkinsons disease is the on-going degeneration. Therefore, trials were conducted to halt the degeneration process. Experiments using the neuropreotective agents such as glial cell-line derived neuropreotective factor or GDNF showed promising results. However, the potential for targeted delivery is yet to be achieved which otherwise may result in adverse effects due to off-target response. Experiments on mice model and on 5 people in advance stage disease in phase 1 trial gave promising results after 2 years. In these pat ients with GDNF was delivered by pump bilaterally into dorsalputamen. Patients were found with bilateral improvement. However, there remains a scientific challenge of applying the Neurotrophic factors to enhance cell survival for in vivo or ex vivo gene therapy. Current trial with AAV2 using convection-enhanced delivery with dose escalation is expected to meet six months primary outcomes. Another trial including the delivery of neurturin on 12 patients in phase 1 showed high potential after 1 year in 2008 in treating parkinsons disease. Next trial in 2015 using convection-enhanced delivery confirmed safety of nigra after dlivery. Delivery of neurturin using AAV2 vector (CERE-120) into stratum and ventral midbrain enhanced the neuroprotection in PD models and seems necessary alternate approach (Herzog et al. 2013). Conclusion It can be concluded from the above discussion that there are variety of cells having the ability to differentiate into cells that produce neurotrophic factor or dopaminergic neurons. The literature review shows that most experiments that have given promising results were conducted in animal models showing high efficacy. Some of the experiments have been used in human trials. Efficacy and safety assurance is required for translation into human therapy. Future experiments needs to be performed using standardized procedure for each type of Parkinson's disease, kind of cell effected, and the delivery site. Sustainable therapeutic effect may be achieved by the modulation of microenvironment for increasing the efficacy. References Barrow, T.R., 2015. Cell replacement therapy in Parkinson's disease.Bioscience Horizons: The National Undergraduate Research Journal,8. Buttery, P.C. and Barker, R.A., 2014. Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?.Journal of Comparative Neurology,522(12), pp.2802-2816. Canet-Aviles, R., Lomax, G.P., Feigal, E.G. and Priest, C., 2014. Proceedings: Cell Therapies for Parkinson's Disease From Discovery to Clinic.Stem cells translational medicine,3(9), pp.979-991. Hegarty, S.V., O'keeffe, G.W. and Sullivan, A.M., 2014. Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.Neural regeneration research,9(19), p.1708. Herzog, C.D., Brown, L., Kruegel, B.R., Wilson, A., Tansey, M.G., Gage, F.H., Johnson, E.M. and Bartus, R.T., 2013. Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120).Neurobiology of disease,58, pp.38-48. Kim, J.H., Auerbach, J.M., Rodrguez-Gmez, J.A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S.H., Nguyen, J., Snchez-Pernaute, R., Bankiewicz, K. and McKay, R., 2002. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.Nature,418(6893), pp.50-56. Kriks, S., Shim, J.W., Piao, J., Ganat, Y.M., Wakeman, D.R., Xie, Z., Carrillo-Reid, L., Auyeung, G., Antonacci, C., Buch, A. and Yang, L., 2011. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson/'s disease.Nature,480(7378), pp.547-551. Lu-Nguyen, N.B., Broadstock, M., Schliesser, M.G., Bartholomae, C.C., von Kalle, C., Schmidt, M. and Yez-Muoz, R.J., 2014. Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease.Human gene therapy,25(7), pp.631-641. Pawitan, J.A., 2011. Prospect of cell therapy for Parkinson's disease.Anatomy cell biology,44(4), pp.256-264.

Wednesday, April 15, 2020

A Handful of Dust essays

A Handful of Dust essays In Evelyn Waughs, A Handful of Dust, Tony Last exists as an aristocrat whose devotion to Victorian values and beliefs controls and dictates his life; leaving him blind to the unhappiness and boredom his wife, Brenda, experiences due to his primitive and outdated ways. Tonys obsession with the Victorian lifestyle only intensifies with his exposure to the material and transient qualities of the new, emerging society. The rapid development of this society shortens the existence of the Victorian lifestyle and seemingly leaves Tony as the last member of his beloved British society. Unwilling to conform and desperately clinging to his traditional ways, Tony creates his existence as an outsider; rejected and abandoned by society he seeks refuge and familiarity in Hetton. Ironically, it is Tony Lasts devotion and loyalty to the preservation of Hetton that lead to the ultimate destruction of his life. The emerging modern society transforms Victorian culture into a mere memory of the pas t, Tonys overwhelming devotion and loyalty to Hetton create the abandonment, solitude, and destruction he experiences throughout the duration of the novel. The marriage between Brenda and Tony suggests the extermination of Empire, the disillusion with the imperialist development that was intimidating in the modernist period. Tony Last lived his life with order. His loyalty and dedication to his estate was that of outstanding perseverance. But there was not a glazed brick or encaustic tile that was not dear to Tonys heart (13), he cherished every bit of that estate. His estate was entirely rebuilt in the gothic style and is now devoid of interest. He even named the bedrooms in their country estate after characters from the King Arthur stories, with the central clock tower, the dining hall with its hammer-beam roof and pitch-pine minstrels gallery; their bedrooms with their brass bedsteads, all of which the...

Thursday, March 12, 2020

Offer and Acceptance Contract Law Essays

Offer and Acceptance Contract Law Essays Offer and Acceptance Contract Law Essay Offer and Acceptance Contract Law Essay The first element that must be looked into in order to advice the legal positions of Celia and her potential buyers is the character of the advertisement. It has to be distinguished between an advertisement which constitutes an offer or an invitation to treat. An advertisement may be considered an offer if it is clear, precise, definite and leaves nothing open for negotiation. This was established by Leftkowitz v Great Minneapolis Surplus Store involving a case of the sale of two mink scarves and a stole. The phrase â€Å" ? 0,000 for the lot, no offers† could be an element of an offer, indicating that price is not negotiable. It can also be interpreted in such that the bags are sold in a lot therefore, a customer cannot request for a particular bag. As such, this arrangement satisfies the characteristics of an offer. That being said, a customer either accepts the offer or refrain from the entire transaction itself. However, the court should not disregard the possibility that the advertisement may only tantamount to an invitation to treat. The precedent whereby advertisements are considered an invitation to treat was established following the case of Partridge v Crittenden. If Celia’s advertisement was an offer, she would be contractually obliged to sell her goods to every customer even if there is no continuity of stock. Hence, she is liable for breach of contract if there were more acceptances than she can satisfy as only 5 handbags are up for sale. Furthermore, the advertisement does not include further details on the bags and leaves room for negotiation. It states that it is suitable for all tastes and occasion. However, Celia cannot assume her customer’s preferences in terms of colour, manufactured material, strap length and so on. It could be that the advertisement is merely an invitation to treat. Having said that, it is important to bear in mind the factors which sets an offer apart from invitation to treat. When an offer is accepted, a binding agreement immediately exists between an offeror and an offeree. Invitation to treat on the other hand is purely a negotiation to treat and offerors are not bound by legal laws if accepted. Communication of acceptance has to be demonstrated when an offeree’s intention is to accept an offer. It can be in the form of writing, conduct (Carlill v Carbolic Smoke Ball Co. ) or speech. It is of utmost importance to know that acceptance through silence is not permissible in forming a contract, as established by Felthouse v Bindley. Baljit had evidently showed her intentions in purchasing the goods through writing. She posted a letter of acceptance, complying with the stated price without negotiating for further discounts. This could possibly mean that a binding agreement now exists. After all, the advertisement did state â€Å"? 10, 000 for the lot, no offers. † However, not all forms of communication of acceptance could result in a legal binding agreement to exist. Suppose a counter-offer is introduced, the original offer is instantly terminated as established by Hyde v Wrench. In this case, the court should consider if Baljit’s enquiry could give rise to an issue of a counter-offer. However, It could be that the advertisement had inadequate details on methods of payment. Hence Baljit was merely clarifying terms. Clarification of terms on the other hand does not constitute a counter-offer. If so, it could be that Baljit’s acceptance was legit. The element at which the court must now look at is the prescribed mode of acceptance. In legal terms, the mode of acceptance must be adhered to and acceptance is valid upon the stated mode. However, It is held that if the offeree does not adhere to the prescribed mode of acceptance, they cannot be liable for breach of contract unless it is stated that it is the one and only mode. That being, compulsory. This was established by Yates Building v Pulleyn. Looking back at Celia’s case, the prescribed mode of acceptance was through email. However, attached under contact details included phone number and postal address, besides obviously, her email address. With this information, it is not logical to immediately terminate an offer if acceptance is not made through email. Otherwise, why would Celia have posted her postal address? This gives an impression that acceptance through email is not compulsory. Baljit’s choice of acceptance was through post. In line with this, the postal rule states that acceptance by mail is valid on posting. So far as the postal address and postage is included, there is no reason for failure of acceptance. This was established by Adams v Lindsell. As the postal rule applies, Baljit’s acceptance can be deemed successful as her letter was still posted within the timeframe stipulated and can be qualified as a qualified customer. The postal rule does not apply to emailing. The principle of this precedent was initiated from the case of Entores v Miles Far East Corporation. This is held that acceptance through instantaneous mode of communication is only effective once it has been received. It follows that Samantha has complied with the prescribed mode of acceptance. However, when the issue of emailing as a form of acceptance arises, it forms many complications. It is questionable if it can be deemed ‘instantaneous mode of acceptance’ as it may take hours to arrive depending on the route, server and internet provider. Hence when dealing with a business, the seller should state details in terms of the estimated time the email should be received. Upon receiving, only then is the acceptance successful. It is only right that the court look into the specific details of the sent email. If evidence can be shown that the email was sent early in the morning or at least within working hours, Celia may be at fault for not checking her inbox earlier. In this case, the court may be in favour of Samantha. Celia is only prepared to sell her goods to one customer and that may be Baljit. Having verified every case with legal terms, it could be that the goods are successfully sold to Baljit. REFERENCES

Tuesday, February 25, 2020

Gustav Mahler Biography and Professional Activity Essay

Gustav Mahler Biography and Professional Activity - Essay Example Mahler entered the Vienne’s Conservatory. Mahler also entered Vienne’s University, studying philosophy and literature. At the Conservatory, he became friends with the future composer Hugo Wolf. Mahler graduated from the Conservatory but failed to achieve the prestigious silver medal The family of the Composer was very poor. His father Gustav Bernhard Mahler was a traveling salesman, who sold alcoholic beverages, sugar, and household products. His mother came from a family of a small manufacturer, producing soap. Gustav was the second of 14 children. Shortly after the birth of Gustav, his family moved to the small industrial town of Jihlava - an island of German culture in South Moravia, where Bernhard Mahler started a tavern. Here, the future composer felt passionately in love with folk dances and songs of the peoples of Austrian Empire: Austrian, German, Hebrew, Czech, Hungarian, Gypsy, Slovak, and so on. All those sounds later became the part of his musical palette. I n 6 years, Gustav began his studies on the piano, and in 10, he gave his first public concert in Jihlava.Despite the regular instruments, such as piano and violin, Mahler used to apply unusual instruments to create his symphonies. For instance, some of his compositions include tenor horn, guitar, mandolin and even cowbell. One can notice a lot of percussions is Mahler’s symphonies, which is quite a distinguishing feature comparing to other musicians of that time. Gustav Mahler was one of the greatest symphonic composers.

Sunday, February 9, 2020

Awareness of business systems methodologies appropriate to the Essay

Awareness of business systems methodologies appropriate to the analysis of complex international logistics and supply chain systems - Essay Example The first stage as given by Dong, Xu and Song (2013) in analysing a problem situation is to clearly identify the problem or opportunity. In the context of ElMesmary, Song and Dinwoodie (2014), the problem identified can be said to be issues with the strategic/tactical and operational planning problems involved in the container terminal logistics processes in Alexandria. ElMesmary, Song and Dinwoodie (2014) observed that strategic/tactical planning problems arise at the first stage of the planning process for container terminals as planners seek to tackle terminal design problems as part of the overall technical feasibility and performance. Operational planning problems have also been noted to come about when logistics processes are being taken in the container terminals (ElMesmary, Song and Dinwoodie, 2014). The second stage of using HSA in analysing problem situation has been said to involve the description of the situation in its current state via the use of diagrams and open discussion. Based on Azevedo, Ferreira, Dias and Palma. (2009), the following diagram can be used to describe the identified problem with strategic/tactical and operational planning. Based on the diagram given above, the main source of the problem can be said to come from the Alexandria container terminal, which is transmitted in the form of multimodal interfaces and IT systems. As the problem manifests, it becomes further amplified with bottlenecks in the container terminal logistics process which act as noise source. The diagram also shows that the problem identified is received by the strategic/tactical and operational planners and further dropped with the container terminal managers as destination (Kim, 2005). The third stage with the use of the HSA has been said to involve the process of describing the situation as it would ideally be. In this regard, it can be said that the strategic/tactical and operational planning was expected to

Thursday, January 30, 2020

Hepatitis C Essay Example for Free

Hepatitis C Essay Abstract Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). It is difficult for the human immune system to eliminate the virus from the body, and infection with HCV usually becomes chronic. Over decades, chronic infection with HCV damages the liver and can cause liver failure in some people. The hepatitis C virus is transmitted mainly by contact with blood or blood products. The Sharing of contaminated needles among drug users is the most common mode of transmission. In the U.S., more than three million people are chronically infected with HCV. HCV is the leading cause of liver transplantation in the U.S and is a risk factor for liver cancer. Hepatitis C Description Hepatitis C was first identified in 1974. The virus that caused disease was not found until 1989 by Brendan Arena. The infection is sometimes called transfusion hepatitis. The name comes from one possible cause of the disease. It may be transmitted along with blood used in blood transfusions. Since the identification of HCV, tests have been developed to identify the virus. Blood transfusions are no longer a major cause of the disease. Hepatitis C is a disease of the liver caused by a virus. Hepatitis in general is an inflammation of the liver, usually caused by a viral infection. The liver becomes tender and enlarged and is unable to function normally, As a result, toxins that would normally be filtered out by the liver build up in the body and   certain nutrients are not processed and stored, as they should be. Hepatitis C is a slowly progressing disorder. In its more advanced stages it can lead to serious and permanent liver damage and even death. Symptoms The symptoms of Hepatitis C are often very mild in the early stages and can be virtually undetectable. Hepatitis C infection involves an acute initial phase of infection which is usually not noticed and lasts up to six months. During this phase, levels of the virus in the blood rise dramatically until the bodys immune response starts producing antibodies. Although our antibodies fight the virus, in around 75% of cases the virus is not eliminated and approximately three out of four people are left with a chronic (long-term) infection A.   Hepatitis infection can result in liver damage because as the virus reproduces in the liver over time, more and more liver cells are changed and destroyed causing scar tissue. This is called fibrosis. In a small percentage of people experiencing cirrhosis, Fibrosis can lead to a hardening of liver tissue which affects the normal function of the liver, this is called cirrhosis In a small percentage of people experiencing cirrhosis, the condition may lead to liver failure or liver cancer. Hepatitis C affects people differently. Some are not affected by it at all, while others can be affected seriously. Generally speaking, it is believed that around three out of four people with hepatitis C will not go on to develop cirrhosis. Over a 25-50 year period of infection, it is believed that less than one in ten people with hepatitis C would develop liver failure or liver cancer. 170 million people worldwide have Hepatitis C There is no cure for hepatitis C, but medications in some cases can suppress the virus for a long period of time. Treatments Some patients with hepatitis C benefit from treatment with interferon alpha or a combination of sustained response rates and tolerability; however, pegylated interferon will likely   remain the backbone of therapy in the foreseeable future. international research teams have discovered a genetic variation that could identify those people infected with hepatitis C who are most likely to benefit from current treatments. Their genome-wide association study of people   receiving hepatitis C treatment revealed that genetic variants near the interferon gene IL28B were associated with peoples response to treatment. Three per cent of the worlds people are infected with hepatitis C and few are able to clear the virus without treatment. The standard treatment is a combination of pegylated interferon-alpha and ribavirin (PEG-IFN-alpha/RBV). Conclusion Hepatitis C is a virus that causes acute and chronic hepatitis. Over 80% of persons who acquire hepatitis C develop chronic hepatitis. Persons who are chronically infected with hepatitis C are at an increased risk for the development of cirrhosis and liver cancer. No effective vaccine has been developed to prevent hepatitis C. Only one antiviral medication has been shown to be effective in the treatment of hepatitis C. Pegylated interferon alpha and ribavirin combination is licensed for the treatment of hepatitis C, but only about 30% to 50% of persons treated recover completely from this infection. References http://www.emedicinehealth.com/hepatitis c article/ em-htm /08/2009 http://www.Faqs.org health/sick-v2 hepatitis c-descriptions html. Copy right 2009 Walter and Eliza Hall Institute Sep 24,2009 Science daily.com/hepatitis treatment Nancy J. Nordeson The Gale Group 2002 http://www.gale encyclopedia of medicine.com http://www.medicalnews.com/ 08/2009/ articles hepatitis c http://www.cdc.gov/ncidod/aip/research/hepatitis

Wednesday, January 22, 2020

Mirroring an Exposed World :: Dance Dancing Art Papers

Mirroring an Exposed World I recently saw a photography piece, "Dancer" by Irving Penn on exhibit at the Whitney Museum. The striking thing about the photos was not that they were of a nude Alexandra Beller, but that hers is not what one would typically think of as a naked dancer's body. She's not tall and thin with well-defined muscles and barely developed breasts. No. She's fat. Beller took a big risk posing nude for Penn's camera. She dared people to see her as a dancer, not just a fat woman. She dared people to see her as a sex symbol, not just a fat woman. She dared people to see her as an emotional woman- sensitive, powerful, frightened, bold, shy, loving, rebellious. She owns her body, and she challenges the audience to own their hesitation and move past it to see her exposed for the woman she really is. The exhibit made me immediately curious about Beller and her work. Formerly dancing with Bill T. Jones' company, Beller is now choreographing her own works. When I heard she would be presenting her latest work, It's Not You, It's Me at the Joyce Soho, I got out my umbrella and waited for over an hour in a standby line to see her perform. My friends had teased me for wanting to see Beller's show, saying "Wouldn't it be weird. I mean you saw her naked," and "Do you think she'll dance naked too?" But that was one of the reasons I wanted to see the show. I really identified with Beller in many ways. I was deeply impressed with her confidence to pose nude in the first place. Obesity, seen as repulsive, is despised at best, yet politely ignored. But Beller will not be ignored. I wondered what it was that gave her this confidence in her body. And I wondered what she would express with her body in her dance works. I was compelled by the risks she had taken with Penn, and compelled to see what else she would risk. When I saw It's Not You, It's Me, particularly the last piece, 50 Ways to Find a Mate, I was bombarded by feelings of pain, sadness, confusion that come with rejection, insecurities that are connected with bodies and body images. I got the feeling that Beller, though a beautiful and talented dancer is still an imperfect woman who struggles with her self-confidence, especially in romantic relationships.

Monday, January 13, 2020

“Popular Mechanics” by Raymond Carver Essay

Essay discussing the role played by the setting in â€Å"Popular Mechanics.† Analyze the central characters relationship to their surroundings. Does the setting limit the characters options or influence the development of the plot? Does the setting play any significant role in enhancing the theme of the story? â€Å"Popular Mechanics† was written in order to make the audience imagine their own details. The descriptions in this story are very basic and plain, the man and woman in the story are nameless with no clue of physical description, and there is no mention of what city, state or country the story takes place. This allows the reader to picture the surroundings and details of the story in their own way, maybe the reader has heard of or been in similar situations and they can put their own faces and locations into the story. The setting is given in very little detail, but it is also the most detail of any element in the story. The setting is a very important part of the story and is used to symbolize, foreshadow and relate with the events and characters. The setting described in the first paragraph prepares the reader for a dark, uncomfortable story. â€Å"Early that day the weather turned and the snow was melting into dirty water.† (Paragraph 1) All of these elements in the setting outside the house are used as symbols for something inside the house. This shows that something good or pure, â€Å"snow† or relationship, is turning into something ugly, â€Å"dirty water† or separation, and it is happening fast, â€Å"early that day.† The first paragraph continues, â€Å"Streaks of it ran down from the little shoulder-high window that faced the backyard.† (Paragraph 1) This paragraph gives very little detail of the house, but enough to get a mental picture. In this line, â€Å"it† refers to the dirty water which is a symbol for the break down of the relationship of the man and woman. The house is small, shown by  the description of a â€Å"little shoulder-high window.† The story later gives another description that the house is small in paragraph eleven, â€Å"She stood in the doorway of the ‘little kitchen’, holding the baby.† The little kitchen is most likely inside a little house. Even though the reader is never specifically told that the house is little, the audience gets small details that spark something in the reader to imagine a small house. The little house can tie in with the characters fight. The house may be too small for the woman to be comfortable raising a child there, or it may be too small for the man’s pride, both these situations can lead to arguments. The most obvious tie in with the characters and the small house is the fact that it is too small for the both of them, the man is leaving and the woman is glad he is. A bigger house means more success, more pride, and more happiness. All of these elements can possibly lead to a happier relationship. The fact that the window faces the backyard gives the events that go on inside the house a sense of privacy. The neighbors can see what is going on in the front yard; the backyard is used for privacy, when you do not really want everyone to know what you are doing. This description symbolizes the bad relationship that develops and â€Å"runs† through the small house when the doors are closed. The next line foreshadows the events that happen in the house. â€Å"Cars slushed by on the street outside, where it was getting dark. But it was getting dark on the inside too.† Here the story is pointing out that what is going on outside is going on inside too, and the reader should make the correlation at this point. The characters relate to the setting here because they are getting dark on the inside as well; the heart, mind and soul of the characters are growing dark feelings. The fact that it is â€Å"getting dark on the inside too† shows that things such as daylight, happiness, love and a relationship are coming to an end and things such as darkness, anger, sadness, and hatred are beginning. The setting is also used symbolically in the story when the flower pot is broken, â€Å"In the scuffle they knocked down a flowerpot.† (Paragraph 26) The flowerpot is used to symbolize the breaking up of the man and woman, and the breaking of the baby. Although the rea der is not told if the baby was physically broken, the emotional and mental  damage that a child goes through when their parents separate can be seen as a possibility for the child in the story. The setting sets the tone for the story, symbolizes elements inside the house, relates with the characters and foreshadows the events of the story. All of these elements are very important to the story and they are all given in three short paragraphs (Paragraphs 1, 11, 26). The setting is given the greatest amount of detail while the rest of the story is given almost no detail, only stereotypical behavior. The reader is required to imagine their own timeline, faces, and many other details, but the setting is told to show the overall mood the writer wanted the reader to see. This proves that the setting is a very powerful element to show that the relationship between the man and the woman and everything that surrounds them is going from good to bad and eventually, everything is broken.

Sunday, January 5, 2020

How Many Elements Can Be Found Naturally

There are 118 elements currently on the periodic table. Several elements have only been found in laboratories and nuclear accelerators. So, you may wonder how  many elements can be found naturally. The usual textbook answer is 91. Scientists used to believe that, except for the element technetium, all the elements up to element 92 (uranium)  could be  found in nature. However, it turns out there are other elements that occur in trace amounts naturally. This brings the number of naturally occurring elements to 98. New Naturally Occurring Elements Technetium is one of the newer elements added to the list. Technetium is an ​element with no stable isotopes. It is produced artificially by bombarding samples of molybdenum with neutrons for commercial and scientific uses and was widely believed to be nonexistent in nature. This has turned out to be untrue. Technetium-99 can be produced when uranium-235 or uranium-238 undergoes fission. Minute amounts of technetium-99 have been found in uranium-rich pitchblende. Elements 93–98 (neptunium, plutonium, americium, curium, berkelium, and californium) were all first artificially synthesized and isolated in the Lawrence Berkeley National Laboratory at the University of California, Berkeley. They have all been found in the fallout of nuclear testing experiments and byproducts of the nuclear industry and were believed to exist only in man-made forms. This also turned out to be untrue. All six of these elements have been found in very small amounts in samples of uranium-rich pitchblende. Perhaps one day, samples of element numbers greater than 98 will be identified. List of Elements Found in Nature The elements found in nature are elements with atomic numbers 1 (hydrogen) through 98 (californium). Ten of these elements occur in trace amounts: technetium (No. 43), promethium (61), astatine (85), francium (87), neptunium (93), plutonium (94), americium (95), curium (96), berkelium (97), and californium (98). The rare elements are produced by radioactive decay and other nuclear processes of more common elements. For example, francium is found in pitchblende as the result of alpha decay of actinium. Some elements found today may have been produced by the decay of primordial elements—elements produced earlier in the history of the universe that have since vanished. Native vs. Natural Elements While many elements occur in nature, they might not occur in pure or native form. There are only a few native elements. These include the noble gases, which dont readily form compounds, so they are pure elements. Some of the metals occur in native form, including gold, silver, and copper. Nonmetals including carbon, nitrogen, and oxygen occur in native form. Elements that occur naturally, yet not in native form, include the alkali metals, alkaline earth, and rare earth elements. These elements are found bound in chemical compounds, not in pure form.